Enzymatic Synthesis of Thymol Octanoate, a Promising Hybrid Molecule

Interest in the synthesis and application of thymol esters has increased recent years due to numerous applications associated with its biological activities. The enzymatic octanoate by esterification octanoic acid was explored using soluble lipases immobilized lipase biocatalysts solvent-free systems. Candida antarctica B form most active biocatalyst for this reaction. Different feeding strategies were evaluated maximize production. results suggest that there could be inhibition ester product In way, optimal reaction condition given a thymol/acid molar ratio 1:4 mol/mol. Under these conditions conversion close 94% maintained more than 90% initial activity after reaction, showing potential enzyme used successive cycles.